Mutational profile, 2%, tissue biopsy
Code: 4412
The availability and turnaround time of this test should be confirmed with the unit before collection.
- Method
- Next-generation sequencing (NGS)
- Collection requirements
- Biopsy or surgical specimens
- Sample stability
- Room temperature
- Turnaround time
- 30 working days
- Preparation and notes
- IMPORTANT: 1. 5 sections with >70% tumor area are required, ideally without necrotic areas, sent in one or more properly labeled Eppendorf tubes (1.5-2 mL). 2. Alternatively, send the sample from the original block. 3. The sections or block must be sent together with a serial section stained with hematoxylin and eosin. 4. Send the pathology report for the specimen(s) to be studied. 5. Paraffin blocks and/or paraffin curls must be sent to the laboratory properly packed in a sealed envelope. Sections must be sent to the laboratory within 5 days of cutting.
Genes tested
Mutation hotspots in 50 cancer-related genes (ABL1, EGFR, GNAS, KRAS, PTPN11, AKT1, ERBB2, GNAQ, MET, RB1, ALK, ERBB4, HNF1A, MLH1, RET, APC, EZH2, HRAS, MPL, SMAD4, ATM, FBXW7, IDH1, NOTCH1, SMARCB1, BRAF, FGFR1, JAK2, NPM1, SMO, CDH1, FGFR2, JAK3, NRAS, SRC, CDKN2A, FGFR3, IDH2, PDGFRA, STK11, CSF1R, FLT3, KDR, PIK3CA, TP53, CTNNB1, GNA11, KIT, PTEN e VHL